中药资源科学与工程研究中心
黄慧才
发布时间:2021-02-22      来源:       点击:

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黄慧才,博士,研究员,博士生导师,广东省珠江人才计划-青年拔尖人才,广东省南药产业技术体系创新团队岗位专家。主要从事药物导向的手性合成及中药活性成分发现等领域的基础应用研究,以第一作者/通讯作者在Angew. Chem. Int. Ed.,Organic Letters,Chemical Communications,Organic Chemistry Frontiers等领域高影响期刊发表论文30余篇,主持国家自然科学基金、广州市科技局等多个项目。

E-mail: huanghc@gzucm.edu.cn

主页:https://www.x-mol.com/groups/huang_huicai

学习工作经历

2016-至今  beat365 手机版官方网站中药资源科学与工程研究中心,研究员

2015-2016  科罗拉多州立大学,博士后

2012-2015  得州大学圣安东尼奥分校,博士后

2007-2012  华东理工大学,药物化学,博士

2003-2007  西南民族大学,制药工程,学士

研究领域及方向

不对称有机催化,光催化不对称合成

岭南药用植物抗肿瘤活性成分发现和修饰

科研及教学课题

1.国家自然科学基金青年项目  2021-2023,主持

2.广州市科技计划项目  2021-2023,主持

3.珠江人才计划青年拔尖人才项目  2017-2021,主持

4.beat365 手机版官方网站杏林青年学者启动基金  2016-2020,主持

5.广东省南药(化橘红)产业技术体系创新团队  岗位专家

部分研究论文

1.Yuzhen Chen, Yichen Wang, Shuzhong Wang, Yan-Yan Ma, Deng-Gao Zhao, Ruoting Zhan, and Huicai Huang*. Asymmetric Construction of Cyclobutanes via Direct Vinylogous Michael Addition/Cyclization of β,γ-Unsaturated Amides. Org. Lett., 2020, 22, 7135-7140. Highlighted by ChemBeanGo,https://www.chembeango.com/zixun/52889

2.Juzhang Yan, Xiaoping Li, Yuzhen Chen, Ying Li, Weiwen Chen, Ruoting Zhan, and Huicai Huang*. Organocatalytic 1,4-Addition of Azadienes with 3-Homoacyl Coumarins toward Highly Enantioenriched Benzofuran Coumarin Skeletons. J. Org. Chem., 2020, 85,12175-12186.

3.Yili Zhang, Xue Lu, Yichen Wang, Hui Xu, Ruoting Zhan, Weiwen Chen, and Huicai Huang*. Regiodivergent Vinylogous−Cyclization Reactions of Cyclic α‑AmideEnone Acceptors: Synthesis of Highly Enantioenriched Heterobicyclic Structures. Org. Lett., 2019, 21, 10069-10074. Highlighted by ChemBeanGo,https://www.chembeango.com/zixun/48896

4.Jialiang Qin, Yili Zhang, Cuiting Liu, Jun Zhou, Ruoting Zhan, Weiwen Chen, Huicai Huang*. Asymmetric Inverse-Electron-Demand Diels–Alder Reaction of β,γ-Unsaturated Amides through Dienolate Catalysis. Org. Lett., 2019, 21, 7337-7341.

5.Xiaoping Li, Juzhang Yan, Jialiang Qin, Shilin Lin,Weiwen Chen, Ruoting Zhan, Huicai Huang*. Enantioselective Synthesis of Benzofuran-Fused N-Heterocycles via Chiral Squaramide Catalyzed [4+2] Cyclization of Azadienes with Azlactones. J. Org. Chem., 2019, 84, 8035-8045.

6.Xue Lu#, Yili Zhang#, Yichen Wang, Yuzhen Chen, Weiwen Chen, Ruoting Zhan, John Zhao, Huicai Huang*. Asymmetric Catalysis Using Modularly Designed Organocatalysts: Synthesis of Fused Tricyclic Pyrano-Pyrano[2,3-c]pyrrol Derivatives. Adv. Synth. Catal., 2019, 361,3234-3238. (#equal contribution)

7.Huicai Huang*, Xue Lu, Yukang Mao, Jinxing Ye*. Asymmetric synthesis of highly functionalized furanones via direct Michael reactions mediated by a bulky primary amine. Org. Chem. Front., 2019, 6, 1080-1083. 封面文章

8.Huicai Huang, Swapna Konda, John C.-G. Zhao*.Diastereodivergent catalysis using modularly designedorganocatalysts: Synthesis of both cis- and trans-fused pyrano[2,3-b]pyrane. Angew. Chem. Int. Ed., 2016, 55, 2213-2216.

9.Huicai Huang, Kailong Zhu, Wenbin Wu, ZhichaoJin, Jinxing Ye*. Highly diastereoselective and enantioselective Michael addition of 5 H-oxazol-4-ones to α, β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability. Chem. Commun., 2012, 48, 461-463.

10.Huicai Huang, Zhichao Jin, Kailong Zhu, Xinmiao Liang, Jinxing Ye*. Highly diastereo-and enantioselective synthesis of 5-substituted 3-pyrrolidin-2-ones: Vinylogous Michael addition under multifunctional catalysis. Angew. Chem. Int. Ed., 2011, 50, 3232-3235.

11.Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric vinylogous Michael reaction of α, β-unsaturated ketones with γ-butenolide under multifunctional catalysis. Chem. Commun., 2010, 46, 5957-5959.

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